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与CORTECS，CSH和BEH颗粒相比，ACQUITY UPLC HSS色谱柱为极性与非极性分析物提供更理想、更平衡的保留效果。经过工艺优化的硅胶颗粒，其机械强度与稳定性更能耐受。UPLC系统操作压力。5种差异较大的键合相，提供更宽泛的选择空间，除了传统的疏水反相保留机理之外，还有偶极-偶极、芳香与氢键相互作用。
ACQUITY UPLC HSS C18 SB色谱柱是一种未封端、低覆盖度硅胶基质C18化学，可为受硅醇基作用影响的化合物提供其它选择性。HSS C18 SB色谱柱硅醇活性提高，使得碱性化合物的保留更强(由于与残留硅醇基的次级作用)，同时降低了对非碱性分析物的保留
(由于其低配体密度以及离子推斥性)。该保留特征的组合产生了一种有用的方法开发工具，可为碱性分析物提供不同的选择性(SB：Selectivity for Bases)，同时还可保持优异峰形。
A rapid and simple LC-MS/MS method was developed and validated for the simultaneous estimation of sofosbuvir (SF) and its metabolite GS-331007 (GS) using famotidine as an internal standard (IS). The Xevo TQD LC-MS/MS was operated under the multiple-reaction monitoring mode using electrospray ionization. Extraction with ethyl acetate was used in sample preparation. The prepared samples were chromatographed on Acquity UPLC HSS C18 (50 mm × 2.1 mm, 1.8 μm) column by pumping 0.1% formic acid and acetonitrile (50:50, v/v) in an isocratic mode at a flow rate of 0.3 ml/min. Method validation was performed as per the FDA guidelines and the standard curves were found to be linear in the range of 10–2500 ng/ml for both SF and its metabolite. The intra-day and inter-day precision and accuracy results were within the acceptable limits. A very short run time of 1.2 min made it possible to analyze more than 300 human plasma samples per day. The developed assay method was successfully applied to a bioequivalence study in human volunteers.
品名 | 编号 |
ACQUITY - Xselect HSS C18 Method Transfer Kit, 100Å, 1.8 - 5 µm, 2.1 - 4.6 mm X 50 - 100mm, 2/pkg | 186004968 |
ACQUITY - Xselect HSS C18 Method Transfer Kit, 100Å, 1.8 - 5 µm, 2.1 - 4.6 mm X 50 - 150mm, 2/pkg | 186004961 |
ACQUITY - Xselect HSS C18 SB Method Transfer Kit, 100Å, 1.8 - 3.5 µm, 2.1 - 4.6 mm X 50 - 100mm, 2... | 186004970 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 1 mm X 100 mm, 1/pkg | 186003530 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 1 mm X 150 mm, 1/pkg | 186003531 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 3 mm X 30 mm, 3/pkg | 176001817 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 3 mm X 50 mm, 3/pkg | 176001818 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 3 mm X 100 mm, 3/pkg | 176001819 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 1 mm X 50 mm, 3/pkg | 176001121 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 2.1 mm X 30 mm, 3/pkg | 176001398 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 2.1 mm X 150 mm, 3/pkg | 176001126 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 1 mm X 100 mm, 3/pkg | 176001122 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 1 mm X 150 mm, 3/pkg | 176001123 |
ACQUITY UPLC HSS C18 Method Validation Kit, 100Å, 1.8 µm, 2.1 mm X 150 mm, 3/pkg | 186006026 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 2.1 mm X 50 mm, 3/pkg | 176001124 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 2.1 mm X 100 mm, 3/pkg | 176001125 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 2.1 mm X 150 mm, 1/pkg | 186003534 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 2.1 mm X 100 mm, 1/pkg | 186003533 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 2.1 mm X 30 mm, 1/pkg | 186003987 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 2.1 mm X 50 mm, 1/pkg | 186003532 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 3 mm X 30 mm, 1/pkg | 186004682 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 3 mm X 50 mm, 1/pkg | 186004683 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 3 mm X 100 mm, 1/pkg | 186004684 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 3 mm X 150 mm, 1/pkg | 186004685 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 3 mm X 75 mm, 1/pkg | 186005618 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 2.1 mm X 75 mm, 1/pkg | 186005615 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 3 mm X 150 mm, 3/pkg | 176001820 |
ACQUITY UPLC HSS C18 Column, 100Å, 1.8 µm, 1 mm X 50 mm, 1/pkg | 186003529 |
ACQUITY UPLC HSS C18 VanGuard Pre-column, 100Å, 1.8 µm, 2.1 mm X 5 mm, 3/pkg | 186003981 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 3 mm X 150 mm, 1/pkg | 186004689 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 2.1 mm X 30 mm, 3/pkg | 176001559 |
ACQUITY UPLC HSS C18 Method Validation Kit, 100Å, 1.8 µm, 2.1 mm X 50 mm, 3/pkg | 186004057 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 1 mm X 50 mm, 3/pkg | 176001556 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 1 mm X 100 mm, 3/pkg | 176001557 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 1 mm X 150 mm, 3/pkg | 176001558 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 3 mm X 100 mm, 1/pkg | 186004826 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 2.1 mm X 100 mm, 1/pkg | 186004119 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 2.1 mm X 30 mm, 1/pkg | 186004117 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 2.1 mm X 50 mm, 1/pkg | 186004118 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 1 mm X 100 mm, 1/pkg | 186004115 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 1 mm X 150 mm, 1/pkg | 186004116 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 3 mm X 30 mm, 1/pkg | 186004686 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 3 mm X 100 mm, 3/pkg | 176001823 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 2.1 mm X 75 mm, 1/pkg | 186005616 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 3 mm X 150 mm, 3/pkg | 176001824 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 2.1 mm X 150 mm, 1/pkg | 186004120 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 3 mm X 30 mm, 3/pkg | 176001821 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 2.1 mm X 150 mm, 3/pkg | 176001562 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 2.1 mm X 100 mm, 3/pkg | 176001561 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 2.1 mm X 50 mm, 3/pkg | 176001560 |
ACQUITY UPLC HSS C18 Method Validation Kit, 100Å, 1.8 µm, 3 mm X 100 mm, 3/pkg | 186004704 |
ACQUITY UPLC HSS C18 Method Validation Kit, 100Å, 1.8 µm, 3 mm X 50 mm, 3/pkg | 186004703 |
ACQUITY UPLC HSS C18 SB VanGuard Pre-column, 100Å, 1.8 µm, 2.1 mm X 5 mm, 3/pkg | 186004136 |
ACQUITY UPLC HSS C18 SB Method Validation Kit, 100Å, 1.8 µm, 2.1 mm X 150 mm, 3/pkg | 186006027 |
ACQUITY UPLC HSS C18 SB Method Validation Kit, 100Å, 1.8 µm, 2.1 mm X 50 mm, 3/pkg | 186004137 |
ACQUITY UPLC HSS C18 SB Method Validation Kit, 100Å, 1.8 µm, 2.1 mm X 100 mm, 3/pkg | 186004138 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 3 mm X 50 mm, 3/pkg | 176001822 |
ACQUITY UPLC HSS C18 SB Column, 100Å, 1.8 µm, 3 mm X 75 mm, 1/pkg | 186005619 |
ACQUITY UPLC HSS C18 SB Method Validation Kit, 100Å, 1.8 µm, 3 mm X 50 mm, 3/pkg | 186004705 |
ACQUITY UPLC HSS C18 SB Method Validation Kit, 100Å, 1.8 µm, 3 mm X 100 mm, 3/pkg | 186004709 |
摘要:*分离技术；多种键合相技术
[详细]
摘要:表面带电杂化颗粒技术
[详细]
摘要:增强对极性化合物和代谢物
[详细]
摘要:五氟苯基；分离异构性的、
[详细]
摘要:极性分析物的保留、HILIC
[详细]
摘要:水的氨基甲酸酯官能团(极性
[详细]
摘要:三键键合的苯己基配体、分
[详细]
摘要:三键键合的酰胺基(Amide)键
[详细]
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